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Bones on the top and sides of the skull develop when fibrous membrane areas ossify (convert) into bone. The bones of the limbs, ribs, and vertebrae develop when cartilage models of the bones ossify into bone. Discuss the processes by which the brain-case bones of the skull are formed and grow during skull enlargement. The brain-case bones that form the top and sides of the skull are produced by intramembranous ossification. In this, mesenchyme from the sclerotome portion of the somites accumulates at the site of the future bone and differentiates into bone-producing cells.